HLA-G monoclonal antibody, clone 5A6G7 (PE)
产品名称: HLA-G monoclonal antibody, clone 5A6G7 (PE)
英文名称: HLA-G monoclonal antibody, clone 5A6G7 (PE)
产品编号: MAB4489
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against synthetic peptide HLA-G.
- Immunogen:
- A synthetic peptide (conjugated with OVA) corresponding to C-terminus of human soluble HLA-G5 and HLA-G6.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- This antibody allows to discriminate between soluble HLA-G protein yielded by shedding from membrane-bound HLA-G forms that do not contain the intron 4-encoded epitope and soluble HLA-G5/HLA-G6 produced from intron 4-retaining alternatively spliced mRNAs. HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells.
- Form:
- Liquid
- Conjugation:
- PE
- Concentration:
- 0.1 mg/mL
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (0.2% BSA, 15 mM sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (10 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Modulation of HLA-G expression in human neural cells after neurotropic viral infections.
Lafon M, Prehaud C, Megret F, Lafage M, Mouillot G, Roa M, Moreau P, Rouas-Freiss N, Carosella ED.J Virol. 2005 Dec;79(24):15226-37.
- 2.
- Indoleamine 2,3 dioxygenase and human leucocyte antigen-G inhibit the T-cell alloproliferative response through two independent pathways.
Le Rond S, Gonzalez A, Gonzalez AS, Carosella ED, Rouas-Freiss N.Immunology. 2005 Nov;116(3):297-307.
- 3.
- Report of the Wet Workshop for Quantification of Soluble HLA-G in Essen, 2004.
Rebmann V, Lemaoult J, Rouas-Freiss N, Carosella ED, Grosse-Wilde H.Hum Immunol. 2005 Aug;66(8):853-63. Epub 2005 Jul 20.
- Application Image
- Western Blot
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry (Frozen sections)
- Immunocytochemistry
- ELISA
- Flow Cytometry
- Entrez GeneID:
- 3135
- Gene Name:
- HLA-G
- Gene Alias:
- MHC-G
- Gene Description:
- major histocompatibility complex, class I, G
- Gene Ontology:
- Hyperlink
- Gene Summary:
- HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq
- Other Designations:
- HLA class I molecule,HLA-G histocompatibility antigen, class I, G,MHC class I antigen,OTTHUMP00000039485,b2 microglobulin
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- Abortion, Habitual
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